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総論・分野の見取り図
- Miekisch W, Schubert JK, Noeldge-Schomburg GFE. Diagnostic potential of breath analysis — focus on volatile organic compounds. Clin Chim Acta 2004;347:25–39. 入門
- Boots AW, van Berkel JJBN, Dallinga JW, et al. The versatile use of exhaled volatile organic compounds in human health and disease. J Breath Res 2012;6(2):027108.
- Buszewski B, Kęsy M, Ligor T, Amann A. Human exhaled air analytics: biomarkers of diseases. Biomed Chromatogr 2007;21:553–566.
ヒト揮発物・volatilome（何が呼気に含まれるか）
- Amann A, de Lacy Costello B, Miekisch W, et al. The human volatilome: VOCs in exhaled breath, skin emanations, urine, feces and saliva. J Breath Res 2014;8(3):034001. ↗ 基準
- de Lacy Costello B, Amann A, Al-Kateb H, et al. A review of the volatiles from the healthy human body. J Breath Res 2014;8(1):014001. ↗
- Pauling L, Robinson AB, Teranishi R, Cary P. Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. PNAS 1971;68(10):2374–2376. ↗ 原点
- Drabińska N, Flynn C, Ratcliffe N, et al. A literature survey of volatiles from the healthy human breath and bodily fluids: the human volatilome. J Breath Res 2021;15:034001.
がん・疾患バイオマーカー
- Haick H, Broza YY, Mochalski P, Ruzsanyi V, Amann A. Assessment, origin, and implementation of breath volatile cancer markers. Chem Soc Rev 2014;43(5):1423–1449. ↗ がん基幹
- Hakim M, Broza YY, Barash O, et al. Volatile organic compounds of lung cancer and possible biochemical pathways. Chem Rev 2012;112(11):5949–5966.
- Broza YY, Haick H. Nanomaterial-based sensors for detection of disease by volatile organic compounds. Nanomedicine 2013;8(5):785–806.
技術・電子鼻・センサ
- Röck F, Barsan N, Weimar U. Electronic nose: current status and future trends. Chem Rev 2008;108(2):705–725. e-nose
- Wilson AD, Baietto M. Applications and advances in electronic-nose technologies. Sensors 2009;9(7):5099–5148.
- Bruderer T, Gaisl T, Gaugg MT, et al. On-line analysis of exhaled breath (SESI-MS ほかリアルタイム質量分析). Chem Rev 2019;119(19):10803–10828.
呼吸器・臨床応用
- van der Schee MP, Paff T, Brinkman P, et al. Breathomics in lung disease. Chest 2015;147(1):224–231.
- Fens N, van der Schee MP, Brinkman P, Sterk PJ. Exhaled breath analysis by electronic nose in airways disease. Clin Exp Allergy 2013;43(7):705–715.
方法論・標準化・検証（必読）
- （コンセンサス） Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers. Am J Respir Crit Care Med 2024;210(9):1079. ↗ 検証
- Henderson B, Ruszkiewicz DM, Wilkinson M, et al. A benchmarking protocol for breath analysis: the Peppermint experiment（Peppermint Initiative）. J Breath Res 2020;14:046008.
- Beauchamp J. Inhaled today, not gone tomorrow: pharmacokinetics and environmental exposure considerations in breath. J Breath Res 2011;6(3):037101.
- Pleil JD, Stiegel MA, Risby TH. Clinical breath analysis: discriminating between human endogenous compounds and exogenous (environmental) chemical confounders. J Breath Res 2013;7:017107.